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May 13 2016

FDA Says These Antibiotics are NOT Worth the Risk

DrAllisonGandre Uncategorized

http://www.medscape.com/viewarticle/863256?nlid=104888_3901

 

The US Food and Drug Administration (FDA) said today that unless they lack other treatment options, patients with uncomplicated infections should not receive fluoroquinolones, given the risk for disabling and potentially permanent adverse events.

Labels for these antibiotics already warn about the risks for tendonitis, tendon rupture, central nervous system effects, peripheral neuropathy, myasthenia gravis exacerbation, QT prolongation and torsades de pointes, phototoxicity, and hypersensitivity. These adverse events can occur together. The FDA will update the labels to state that the serious risks posed by fluoroquinolones generally outweigh their benefits for patients with sinusitis, bronchitis, and uncomplicated urinary tract infections that are treatable by other means.

There are seven FDA-approved fluoroquinolones for systemic use on the market:

  • moxifloxacin (Avelox, Merck),
  • ciprofloxacin (Cipro, Bayer HealthCare),
  • ciprofloxacin extended-release,
  • gemifloxacin (Factive, LG Life Sciences, Inc),
  • levofloxacin (Levaquin, Janssen Pharmaceuticals Inc),
  • moxifloxacin injection, and
  • ofloxacin (available only as a generic).

An FDA advisory panel in November 2015 recommended stronger label warnings for the antibiotics, given widespread reports of adverse events.

More information about today’s announcement is available on the FDA website.

To report any problems with fluoroquinolones, contact MedWatch, the FDA’s safety information and adverse event reporting program, by telephone at 1-800-FDA-1088; by fax at 1-800-FDA-0178; online at https://www.accessdata.fda.gov/scripts/medwatch/medwatch-online.htm; with postage-paid FDA form 3500, available at http://www.fda.gov/MedWatch/getforms.htm; or by mail to MedWatch, 5600 Fishers Lane, Rockville, Maryland 20852-9787.

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